Career Profile

Highly analytical and skilled bioinformatics analyst dealing with biology problems including translational control, lipid metabolism and tumor immunotherapy. Now, I’m a postdoctoral researcher in Wuhan University, and a bioinformatics with 9 years of experience in computational biology, intergration algorithms, and genomic datasets. Currently I am exploring statin resistance mechanisms in song lab and developing human diseases cures.

Experiences

Bioinformatic researcher

July 2016 - 2019 July
BGI research

Being a bioinformatics analyst, I collaborated with my colleagues to research in rubber project. I fininshed the re-sequencing section independently. I also used WDL and python to construct automatic pipeline in WGS and WES for cancer treatment. I was also involved in the pre-development work of the spatial transcriptome. As a lecturer of BGI College, I am also responsible for the training of college interns from WHU, HUST and HZAU in Wuhan.

  • Analysis of cooperative projects
  • Automatic bioinfomatic pipelines
  • Training of college interns

Bioinformatics and AI

July 2019 - September 2020
Genoimmune, BGI

In the department of bioinformatic in Genoimmune, my work mainly includes deep learning model building for neoantigen affinity prediction. Meanwhile, I also update the EPIP (epitope presentation integrated prediction) software.

  • Building deep learning model in neoantigen affinity prediction
  • Update EPIP, a machine learning software for MHC affinity prediction

POST-DOC

September 2024 - Now
WHU, college of life sciences

Using bioinformatics and AI tech to investigate lipid metabolism in song lab.

  • Building multi-omics and deep learning model in lipid and cholesterol metabolism.
  • Statins resistance mechanism

Projects

The following are some of the projects I have participated in, the details are as follows:

Multi-omics - Multi-omics maps of cotton fibre reveal epigenetic basis for staged single-cell differentiation.
Rubber Tree - The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis.
EPIP - EPIP: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles
Multi-Pan - A comprehensive deep learning model for MHC epitope prediction.
Automatic pipeline construction - Automatic pipeline construction in spatial transcriptome
Genomic feature extraction - Genomic feature extraction in bioinformatics
Human lipid metabolism - Human multi-omics analysis

Publications

I list some publications in this section. Described below.

  • Multi-omics maps of cotton fibre reveal epigenetic basis for staged single-cell differentiation
  • Maojun Wang, Pengcheng Wang, Lili Tu, Sitao Zhu, Lin Zhang, Zhonghua Li, Qinghua Zhang, Daojun Yuan, Xianlong Zhang.
    Nucleic Acids Res. 2016
  • GhJAZ2 negatively regulates cotton fiber initiation by interacting with the R2R3-myb transcription factor GhMYB25-like
  • Haiyan Hu, Xin He, Lili Tu, Longfu Zhu, Sitao Zhu, Zonghe Ge, Xianlong Zhang.
    Plant J. 2016
  • Identification of 12 cancer types through genome deep learning
  • Yingshuai Sun, Sitao Zhu, Kailong Ma, Weiqing Liu, Yao Yue, Gang Hu, Huifang Lu & Wenbin Chen.
    Sci Rep. 2019
  • Plant HEM1 specifies a condensation domain to control immune gene translation
  • Yulu Zhou, Ruixia Niu, Zhijuan Tang, Rui Mou, Zhao Wang, Sitao Zhu, Hongchun Yang, Pingtao Ding & Guoyong Xu.
    Nat. Plants. 2023
  • RNAirport: a deep neural network-based database characterizing representative gene models in plants
  • Sitao Zhu, Shu Yuan, Ruixia Niu, Yulu Zhou, Zhao Wang, Guoyong Xu.
    J. Genet. Genomics. 2024
  • Genetically-encoded targeted protein degradation technology to remove endogenous condensation-prone proteins and improve crop performance
  • Ming Luo, Sitao Zhu, Hua Dang, Qing Wen, Ruixia Niu, Jiawei Long, Zhao Wang, Yongjia Tong, Yuese Ning, Meng Yuan & Guoyong Xu.
    Nat Commun, 2025.

    Skills & Proficiency

    Biology & Bioinformatics

    Python & Django

    Linux

    HTML5 & CSS

    Adobe Illustrator

    R & RStudio